Andrew S
We found 9 articles
I’ve already covered how to easily manage carboxylic acid derivative formation and manipulation using the Reactivity Hill. Say we’re tired of whatever derivative we just created and want to bring the derivative back to its parent acid (the particular acid the derivative came from). There are two ways to “take home” any acid-derivative. We can ...
A lot of students get overwhelmed with all the manipulations we can do with carboxylic acids and their derivatives. Outside of being able to deprotonate carboxylic acids if we so desire, we can also directly derivatize them. For example, we can transform them into acid chlorides. Acid anhydrides. Esters. Amides. We can also transform acid ...
As I’m sure you’ve noticed by now, accurate bookkeeping of your carbon-count is seemingly petty but actually important: an error in bookkeeping can lead you to an incorrect answer even if your logic is correct. With this in mind I thought it’d be helpful to share four common abbreviations that fluster many students.
Your professor gives you the below molecule. Can you quickly determine the hybridization of every atom? Determining and understanding hybridization in Orgo 1 isn’t a futile practice. It’s an idea key to understanding mechanism and reactivity all the way through Orgo 2. Thankfully, the rules of thumb used to determine an atom’s hybridization are ...
A common exam question that comes up in both Orgo 1 and Orgo 2 requires students to determine a reaction’s equilibrium position. The question usually looks something like this:
We all know Orgo 1 professors love stereoisomers. Consider the equation A + B = C. Most professors expect you to fill in the question mark with all possible products and then indicate the major product(s), while other professors may provide you a potential C and then ask you if the statement is True or False.
So your professor says your Orgo 1 final will have a few synthesis problems. The good news: you’ve only learned a handful of reactions. Namely, you’ve learned how to manipulate alkenes and alkynes, and you know a little about radicals, substitution versus elimination, and the chemistry of alcohols, thiols, ethers, and epoxides. The bad news: ...
Determining which of two molecules is more acidic is tricky if you haven’t yet organized those factors that influence acidity. The protocol is a method I learned from my mastermind Orgo 2 professor to keep these ideas in order when they come into conflict. Namely: Size is more important than Electronegativity, which is more important than ...
We’ve all been there. After months of anticipation, we get the letter, either digitally or via “snail mail”, that will dictate the course of our lives for the next 1,2, 4 or in some cases (e.g. doctoral programs) 10 years. Sure, getting through all the applications, soliciting letters of recommendation, and polishing our statements of purpose like ...